Whole Exome Sequencing Whole exome sequencing (WES) (81415 with or without 81416) is medically necessary for any of the following clinical scenarios when all of the general criteria for WES testing (below) are also met. In the regions targeted by WES capture (81.5% of the consensus coding genome), the mean numbers of single-nucleotide variants (SNVs) and small insertions/deletions (indels) detected per sample were 84,192 and 13,325, respectively, for WES, and 84,968 and 12,702, respectively, for WGS. I was wondering whether to get WGS or WES to perform this experiment:- WES refers to the sequence determination of the exome. Ask Question Asked 3 years, 11 months ago. The laboratory must then fax the With whole exome sequencing, that can change during the investigation. HUSKY Health Program Whole Exome Sequencing and Whole Genome Sequencing Prior Authorization Request Form* Phone: 1.800.440.5071 This form MUST be completed and signed by the ORDERING PROVIDER and sent with clinical documentation to the laboratory performing the testing. XomeDx, or exome sequencing (ES), can be used to identify the underlying molecular basis of a genetic disorder in an affected individual and is best suited for patients who have a genetic condition that routine genetic testing has not been able to identify. Phenotype Suspicious for a Genetic Diagnosis In that situation certain genes must be included, so hopefully you know about that ahead of time.” Limitations of the chemistry are preventing them from moving to whole exome or whole genome platforms. 1 $\begingroup$ I am working on a project where I want to discover causative genes for a certain disease I may have. Active 3 years, 10 months ago. Whole Genome Sequencing vs Whole Exome Sequencing. Why do the commercial genetic test providers go the route of whole-exome sequencing (WES), instead of whole-genome sequencing (WGS)? Whole exome sequencing (WES) is a type of genetic testing that is used to determine the nucleotide sequence (or DNA sequence) of the exonic (the expressed or protein-coding) regions of an individual’s genome. Exome panels are commercially available, they don’t need to be customised or designed. Advantages of Whole Exome sequencing include: If your study is discovery-based, i.e. Determining the order of DNA building blocks (nucleotides) in an individual's genetic code, called DNA sequencing, has advanced the study of genetics and is one technique used to test for genetic disorders. Whole Genome Sequencing (WGS) and Whole Exome Sequencing (WES) are increasingly clinically available due to significant advances in DNA sequencing technology over the last several years (Taber et al., 2014). 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